Electrochemical and biological performance of hierarchical platinum-iridium electrodes structured by a femtosecond laser.

Neural electrode interfaces are essential to the stimulation safety and recording quality of various bioelectronic therapies. The recently proposed hierarchical platinum-iridium (Pt-Ir) electrodes produced by femtosecond lasers have exhibited superior electrochemical performance in vitro, but their in vivo performance is still unclear. In this study, we explored the electrochemical performance, biological response, and tissue adhesion of hierarchical Pt-Ir electrodes by implantation in adult rat brains for 1, 8, and 16 weeks. Regular smooth Pt-Ir electrodes were used as a control. The results showed that the electrochemical performance of both electrodes decreased and leveled off during implantation. However, after 16 weeks, the charge storage capacity of hierarchical electrodes stabilized at ~16.8 mC/cm2, which was 15 times that of the smooth control electrodes (1.1 mC/cm2). Moreover, the highly structured electrodes had lower impedance amplitude and cutoff frequency values. The similar histological response to smooth electrodes indicated good biocompatibility of the hierarchically structured Pt-Ir electrodes. Given their superior in vivo performance, the femtosecond laser-treated Pt-Ir electrode showed great potential for neuromodulation applications.

Investigation of Artifacts and Optimization in Proton Resonance Frequency Thermometry Towards Heating Risk Monitoring of Implantable Medical Devices in Magnetic Resonance Imaging.

OBJECTIVE: Artifacts limit the application of proton resonance frequency (PRF) thermometry for on-site, individualized heating evaluations of implantable medical devices such as deep brain stimulation (DBS) for use in magnetic resonance imaging (MRI). Its properties are unclear and the research on how to choose an unaffected measurement region is insufficient. METHODS: The properties of PRF signals around the metallic DBS electrode were investigated through simulations and phantom experiments considering electromagnetic interferences from material susceptibility and the radio frequency (RF) interactions. A threshold method on phase difference Δϕ was used to define a measurement area to estimate heating at the electrode surface. Its performance was compared to that of the Bayesian magnitude method and probe measurements. RESULTS: The B0 magnetic field inhomogeneity due to the electrode susceptibility was the main influencing factor on PRF compared to the RF artifact. Δϕ around the electrode followed normal distribution but was distorted. Underestimation occurred at places with high temperature rises. The noise was increased and could be well estimated from magnitude images using a modified NEMA method. The Δϕ-threshold method based on this knowledge outperformed the Bayesian magnitude method by more than 42% in estimation error of the electrode heating. CONCLUSION: The findings favor the use of PRF with the proposed approach as a reliable method for electrode heating estimation. SIGNIFICANCE: This study clarified the influence of device artifacts and could improve the performance of PRF thermometry for individualized heating assessments of patients with implants under MRI.